Pathophysiology of respiratory distress syndrome
نویسندگان
چکیده
Respiratory distress syndrome (RDS) is a major cause of neonatal mortality and morbidity, especially in preterm infants. its aetiology includes developmental immaturity of the lungs, particularly of the surfactant synthesizing system. Surfactant is produced, stored and recycled by type ii pneumocytes and is detectable from about 24 weeks’ gestation. it is a mixture of phospholipids, neutral lipids and proteins and is spread as a film over the alveolar surface to lower surface tension and to prevent alveolar collapse. the resulting clinical correlates of RDS can be predicted from the immature lung structure and atelectasis which occur due to surfactant deficiency. Various clinical factors are known to dysregulate surfactant production and function, leading to the development of RDS. apart from preventing the incidence of prematurity, antenatal steroids and prophylactic surfactant are of proven benefit in reducing the incidence of RDS.
منابع مشابه
Study of Demographic Factors Affecting Neonatal Mortality Due to Respiratory Distress Syndrome in Rural Area of Ahvaz in 2010
Introduction: Neonatal mortality rate is an important index of development in different communities and respiratory distress syndrome is one of the important causes. This study aimed to determine the status and effective demographic factors of neonatal mortality due to respiratory distress syndrome in Rural Area of Ahvaz city Iran. Method: It was a case control study of all neonatal death ...
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